TAL effectors (TALEs) are programmable DNA binding proteins that can be easily customized to target novel DNA sequences. TALEs can be used to facilitate precise genome editing and to control transcription of endogenous genes. The genome-engineering.org website contains detailed protocol and reagent information on the open source TALE genome engineering toolbox developed by our group.
Optogenetics tools combine genetic control with fast light switching to achieve targeted modulation of specific groups of neurons in live animals. Detailed reagent information and protocols can be found at the optogenetics.org website.