The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases – owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlying pathogenesis. Technologies that facilitate functional dissection of distinct brain circuits are necessary for systematic identification of disease origin and therapy. Our group is developing and applying molecular and optical technologies for probing brain function in health and disease. We hope that these new approaches will improve our understanding and treatment of brain diseases.

Funding Sources:

  • NIH
  • HHMI
  • Paul G. Allen Family Foundation
  • New York Stem Cell Foundation
  • Simons Foundation
  • Vallee Foundation
  • Poitras Center for Affective Disorders Research at MIT
  • Hock E. Tan and K. Lisa Yang Center for Autism Research at MIT
  • Bob Metcalfe
  • James and Patricia Poitras
  • David Cheng
  • Broad Institute of MIT and Harvard
  • McGovern Institute for Brain Research at MIT